Incidence, Clearance, and Persistence of Anal Human Papillomavirus in Men Who Have Sex with Men Living with Human Immunodeficiency Virus: Implications for Human Papillomavirus Vaccination

JJ Ong; S Walker; A Grulich; J Hoy; TRH Read; C Bradshaw; M Chen; SM Garland; A Cornall; R Hillman; DJ Templeton; J Hocking; B Eu; B Tee; EPF Chow; CK Fairley

Journal article

Incidence, Clearance, and Persistence of Anal Human Papillomavirus in Men Who Have Sex with Men Living with Human Immunodeficiency Virus: Implications for Human Papillomavirus Vaccination

JJ Ong, S Walker, A Grulich, J Hoy, TRH Read, C Bradshaw, M Chen, SM Garland, A Cornall, R Hillman, DJ Templeton, J Hocking, B Eu, B Tee, EPF Chow, CK Fairley

Sexually Transmitted Diseases | Published : 2019

DOI: 10.1097/OLQ.0000000000000958

Abstract

Background Men who have sex with men living with human immunodeficiency virus have a high risk of anal cancer. We estimate the likely benefit of human papillomavirus (HPV) vaccination among participants of the Anal Cancer Examination study. Methods Anal swabs were collected for the detection and genotyping of anal HPV DNA by linear array (Roche Diagnostics) in this 2-year multicenter prospective cohort. We calculated the proportion of men, stratified by age, without detectable vaccine type-specific DNA. Results Overall, 255 men, with a median age of 50 years (interquartile range, 44-56 years) contributed 488.9 person-years of follow-up. After 2 years of follow-up, 149 (58%; 95% confidence in..

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University of Melbourne Researchers

Catriona Bradshaw Author

Suzanne Wark Author

Jane Hocking Author

Eric Chow Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) Program grant (568971). J.J.O., E.P.F.C., and T.R.H.R. are supported by the Australian NHMRC Early Career Fellowships [grant numbers J.J.O., 1104781; E.P.F.C., 1091226; T.R.H.R., 1091536].